Metabolic Syndrome Insulin resistance syndrome – Syndrome X

• A combination of insulin resistance and ↑ risk of 2 DM

Diagnosis is based on any 3 of the following Adult Treatment Panel III criteria

Abdominal obesity  waist circumference > 40 inches in men, > 35 inches in women

TG ≥ 150 mg/dL

HDL < 40 mg/dL in men and < 50 mg/dL in women

BP ≥ 130/85 mmHg

Fasting glucose ≥ 110 mg/dL

Treatment

 • Preventing the development of type 2 DM and coronary vascular disease

. • Focus on lifestyle modifications (diet, weight loss, exercise)

, • if needed, medication for treatment of insulin resistance