[PCM] Merck: Regulatory Update on Cladribine Tablets + Vacancies [1 Attachm

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Pharmacists_ coffee magazineElectronic Edition Edition No. 411, year 4June 24, 2011 Today's edition sent to: 24,421 Arabian Pharmacists
Find Valuable attachment"22 Qs U Should B Prepared 4 Interview" may find attachment at the end of e-mail
Today in Hot pharma news
Medicine of the week  Atorvastatin   Atorvastatin (INN) (pronounced /əˌtɔrvəˈstætən/), sold by Pfizer under the trade name Lipitor, is a member of the drug class known as statins, used for lowering blood cholesterol. It also stabilizes plaque and prevents strokes through anti-inflammatory and other mechanisms. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body. Atorvastatin was first synthesized in 1985 by Bruce Roth while working at Parke-Davis Warner-Lambert Company (now Pfizer). With 2008 sales of US$12.4 billion, Lipitor was the top-selling branded pharmaceutical in the world.[1] US patent protection is scheduled to expire in June 2011.[2][3] However, Pfizer made an agreement with Ranbaxy Laboratories to delay the generic launch in the US until November 2011.[1] Indications: Hypercholesterolemia[4] (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson types IIa and IIb) to reduce total cholesterol, LDL-C,[5] apo-B,[6] Triglycerides[7] levels, and CRP[8] as well as increase HDL levels. Heterozygous familial hypercholesterolemia[4] in pediatric patients Homozygous familial hypercholesterolemia[4][9] Hypertriglyceridemia (Fredrickson Type IV) Primary dysbetalipoproteinemia (Fredrickson Type III) It has also been used in the treatment of combined hyperlipidemia.[10] Secondary prophylaxis in patients with coronary heart disease and multiple risk factors for myocardial infarction, stroke, unstable angina,[11][12] and revascularization.[13][14] Myocardial infarction and stroke prophylaxis in patients with type II diabetes.[15][16][17] Concomitant therapy considerations Atorvastatin may be used in combination with bile acid resins. It is not recommended to combine statin treatment with fibrates because of the increased risk of myopathy related adverse reactions.[18]Drug dose must be adjusted according to age of patient, and must be lowered in Hepatic insufficiency Contraindications Active liver disease: cholestasis, hepatic encephalopathy, hepatitis, and jaundice Unexplained elevations in AST or ALT levels Pregnancy Breast-feeding Precaution must be taken when treating with atorvastatin, because rarely it may lead to rhabdomyolysis,[19] it may be very serious leading to acute renal failure due to myoglobinuria. If rhabdomyolysis is suspected or diagnosed, atorvastatin therapy should be discontinued immediately.[20] Also Atorvastatin should be discontinued if a patient has markedly elevated CPK levels or if a myopathy is suspected or diagnosed. The likelihood of developing a myopathy is increased by the co-administration of cyclosporine, fibric acid derivatives, erythromycin, niacin, and azole antifungals.[18] Atorvastatin is absolutely contraindicated in pregnancy, it is likely to cause harm to fetal development because of the importance of cholesterol and various products in the cholesterol biosynthesis pathway for fetal development, including steroid synthesis and cell membrane production. It is not recommended that nursing mothers take atorvastatin due to the possibility of adverse reactions in nursing infants, since experiments with rats indicate that atorvastatin is likely to be secreted into human milk.	KSA to KSA + Add a vacancy        Medical & Sales Reps New Dermatological Company Is looking to hire Medical representatives in Jeddah with the following criteria: 1 – Vet and science 2 – Age (not more than 30 years) 3 – Experience (minimum 1 year) / Derma or OB Gyna Lines – Jeddah 4 – Presentable with high communication skills 5 – Self confidence / Self Motivated 6 – Excellent command of English Language 7 – Available for immediate hiring. Candidate who fill the above criteria; is requested to send the CV for: jeddahrep@hotmail.com jeddahrep@ hotmail.com   Pharmacists_coffee magazine Female med rep at Riyadh area Leading multinational pharmaceutical company requires a female med rep at Riyadh area Interested candidates send their CVs to: karimgamal303@hotmail.com karimgamal303@ hotmail.com   Pharmacists_coffee magazine Female medical rep. at Qasim area Leading multinational company requires a female medical rep. at Qasim area Interested candidates send their CVs with a recent photo to: m_abdelrazek2007@hotmail.com m_abdelrazek2007@ hotmail.com   Pharmacists_coffee magazine Pharmacy in Jeddah needs a pharmacist for i3ara resident in Jeddah is preferred-having Professional license is a must Tel: 0569968987 - 0541005588 - 0504278762   Pharmacists_coffee magazine Vacancy in K.S.A Fast growing Saudi company , seeking for Medical Representatives for Riyadh Region , candidates to send C.V.s to: marketingmanager@arabseas-sa.com marketingmanager@ arabseas-sa.com   Pharmacists_coffee magazine Derma Pharma Derma Pharma PELLA Pharmaceuticals A New Jordanian  cosmoceutical company operating in Saudi Arabia seeking for immediate hiring male & female medical representative building a new team with the following requirements : Located in Jeddah,Riyadh&Dammam Bachelor Degree in Pharmacy Previous Experience is prefable Age not more than 28 years Having a valid transferable Iqama Good Language& computer Skills Self motivated,reliable,honest,team player and hard worker If you have the above mentioned criteria ,You are kindly requested to send your resume with recent photo within 2 weeks to: dermapharmasa@hotmail.com dermapharmasa@ hotmail.com   Pharmacists_coffee magazine Pharmacy in Mekka Needs pharmacist i3ara Tel: 0566671609   Pharmacists_coffee magazine Medical manager for Saudi Arabia Leading multinational pharmaceutical group requires the services in Saudi Arabia for a: Medical manager Requirements: Education: physician with experience in the pharmaceutical industry is a must Experience: 3 years as a medical manager/advisor in multinational pharmaceutical company Background in diabetes and pharma economics is preferable Objective of the position is to support and provide accurate science and medical knowledge to the company as far as the management of diabetes products and disease management is concerned Appointment is based on the approval of all the required local legal formalities Interested candidates must send their CV's to: hr@gotobingo.org  hr@ gotobingo.org                   Egypt to KSA   + Add a vacancy    New Pharmacies group in Western Area need pharmacists Advanced Pharmacy Group In KSA , need recently graduated and qualified pharmacists. The candidate must be , 1- Recently graduated 2007 to 2011 2- passed the PROMETRIC Exam Kindly send your C.V and a scanned copy of the PROMETRIC exam to my email info@biomdht.com info@ biomdht.com   Pharmacists_coffee magazine Medical manager for Saudi Arabia Leading multinational pharmaceutical group requires the services in Saudi Arabia for a: Medical manager Requirements: Education: physician with experience in the pharmaceutical industry is a must Experience: 3 years as a medical manager/advisor in multinational pharmaceutical company Background in diabetes and pharma economics is preferable Objective of the position is to support and provide accurate science and medical knowledge to the company as far as the management of diabetes products and disease management is concerned Appointment is based on the approval of all the required local legal formalities Interested candidates must send their CV's to: hr@gotobingo.org  hr@ gotobingo.org   Pharmacists_coffee magazine Immediately for KSA Pharmacists required for Saudi Arabia Arab brothers company Tel: 33866644 - 0103011030 Fax: 33866645 www.arab-rec.com   Pharmacists_coffee magazine For Saudi Arabia El-Nagah travels Pharmacists required for Konoz Al-Seha pharmacies & big hospitals 3 Abdel-Halim Al-Bahi St. from Wadi Al-Neel next to Mosa'ab Ben Omer Masjed - Mohandeseen Tel: 33037852 - 33038072 - 33047202 - 0118562222 - 0118563333 - 0145222190 - 0145222191 elnagahcom@yahoo.com elnagahcom@ yahoo.com   Pharmacists_coffee magazine Required for KSA Pharmacists required for Saudi Arabia Alamany company 8 Ahmed Al-Melehy St. from Lotfy Hassona St. - Dokki Tel: 0140666556 - 0122808423 - 33373525 Fax: 33373522 Alamany604@yahoo.com Alamany604@ yahoo.com              + Add a vacancy          Egypt to Egypt  + Add a vacancy       Pharmacy for sale Location: Nasr city Tel: 0110084420 - 26721499 ezeyadah@yahoo.com ezeyadah@ yahoo.com   Pharmacists_coffee magazine Well Established Pharmaceutical Co. Well Established Pharmaceutical Co. Is in need to Medical Representative -Full Time - Resident Alex & Behera -Age not more than 28 years -Self Motivated - Computer Skills - Experience with CVS products is a plus Interested Candidate to send their C.V.s to Dr_sideek@yahoo.com Dr_sideek@ yahoo.com   Pharmacists_coffee magazine EGYPHARMA Egypharma need Full-time product specialists and medical rep Successful candidates should be: Physician, pharmacist, vet, dentist and science Excellent command of English fresh or experience Exceptional & very competitive package will be offered to the right candidates based on experience Please send your CV with a recent photo and mention the Place of residence to: mkandil_egypharma@yahoo.com mkandil_egypharma@ yahoo.com   Pharmacists_coffee magazine Hospital Medical Reps required for EPCI due to expansion in our Anti-Infective business EPCI Pharmaceutical Company seeking the following positions 1-Part-Timer Medical Rep for Hospitals for East Cairo (Ref: HMR East) 2-Part-Timer Medical Rep for Hospitals for West Cairo (Ref: HMR West) Job Profile 1-Promoting 1 anti-infective drug in certain no of  hospitals 2-Main business time will be A.M and in some special cases P.M. the right candidate should be a-Pharmacist,Vet or science graduate b-Fresh graduates or Experienced are welcomed (experience will be preferred) c-Smart,Innovative and Hard Worker d-Have the ability to work within a team if you are interested kindly send your c.v with a recent photo Mentioning (Job Ref and area of residence) in subject to Epci_hr@yahoo.com Epci_hr@ yahoo.com   Pharmacists_coffee magazine Urgently Needed Med. Reps. For Al Andalous Medical Co. urgently required Medical Reps for Cairo. Pharmacy , Vet., Science graduates immediately apply your C.V to m.r.cairo2011@gmail.com m.r.cairo2011@ gmail.com Candidates should be hard worker , smart , team member and willing to learn and succeed. Competitive salary and incentive scheme + Company car after 6 months to be owned. + Medical Insurance.   Pharmacists_coffee magazine HKPI_JV in joint venture with Quintiles HKPI_JV in joint venture with Quintiles is looking for recruiting: Medical Representatives (Cairo & Guiza )  (Ref: FMR) Criteria: 1- Medical Background, preferably Bachelor‘s Degree as Veterinary Medicine , Dentist or Sciences. 2- Fresh graduates or having 1- 2 years experience in similar positions in the Egyptian pharmaceutical field 3- Good Command of English language Benefits: Excellent remuneration package Excellent training curriculum Suitable work environment Successful team members will enjoy the opportunity to join the planned operations in the Gulf and Middle East. Interested candidates should e-mail their CVs including recent photograph within 7 days to: hr@hkpi.net hr@ hkpi.net with job reference as subject. For more information about Quintiles visit our website: www.Quintiles.com All applications will be treated with strict confidentiality.   Pharmacists_coffee magazine Well established national pharmaceutical company A well Established national pharmaceutical Company Is looking for hiring Med. Reps in Dakahlia, Ismailia, Suez, Portsaid and Gharbia. General Conditions & Qualifications: • Medical Background (Pharmacy, Vet , Medicine, Science) • Excellent Communications and time management skills • High profiles Person to join a growing team & ability to learn • Excellent English Written & Reading. Please mention the governorate in the subject and send your updated CV with a  recent photo to hr969@yahoo.com hr969@ yahoo.com   Pharmacists_coffee magazine Medical Student Summer Trainee Fast Growing international pharmaceutical company in Egypt REQUIRES Students in the following faculties Medicine ; pharmacy , vet , science , physiotherapy He/she has the following characters Presentable , hard worker , honest Resident in Cairo or Alex SENT YOUR UPDATED C.V TO sara.ibrahim@nagyresearch.com sara.ibrahim@ nagyresearch.com  & samuel.missiha@nagyresearch.com samuel.missiha@ nagyresearch.com  & diana.akram@nagyreseach.com diana.akram@ nagyreseach.com   Pharmacists_coffee magazine ECCOPHARM Vacancy Eccopharm vacancy Requied for immediate hiring : Fulltime medical represntitave 1- Based at Cairo for helioplles and downtown 2- Based at Giza 1. Age not exeeding 27 2. Previous experience 3. Valid driving licinse Excelent package and own car Send cv with recent photo to: hazouma2004@yahoo.com hazouma2004@ yahoo.com   Pharmacists_coffee magazine Urgently for pharmaceutical company we need : 1- Marketing Manager  (ref. Marketing M) 2-Product Manager (ref PM) 3-product specialist (ref PS+ address) 4-District  Manager (upper Egypt) 5-Area Manager (upper Egypt) very attractive salary + benefits hr-cairo@live.com hr-cairo@ live.com   Pharmacists_coffee magazine 4A – Pharmaceuticals 4A – Pharmaceuticals, Highly specialized in CVS-Drugs  ( Plavicard – Symbian – Cazet

France Suspends Use of Pioglitazone Based on 'Slight' Risk for Bladder Cancer

The antidiabetes drug pioglitazone (marketed in the U.S. as Actos) is to be taken off the market in France because of concerns over a "slightly increased risk" for bladder cancer, Bloomberg reports.
In its announcement, the French drug agency AFSSAPS said that a French cohort of some 155,000 patients with diabetes who were exposed to pioglitazone, when compared with a nonexposed diabetic cohort, showed a statistically significant association between exposure to the drug and the incidence of bladder cancer.
In September 2010 the FDA said it was following a 10-year epidemiological study of the association. Interim results showed an increased risk among patients with the longest exposures and the highest cumulative doses of Actos.